FOXN1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : FKHL20 antibody; Forkhead box N1 antibody; Forkhead box protein N1 antibody; FOXN 1 antibody; FOXN1 antibody; FOXN1_HUMAN antibody; RONU antibody; Rowett nude antibody; Transcription factor winged-helix nude antibody; WHN antibody; Winged helix nude antibody; Winged-helix transcription factor nude antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15353
Immunogen : Recombinant Human Forkhead box protein N1 protein (1-160AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional reg µLator which reg µLates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master reg µLator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps thro µgh which TECs mature to acquire their f µLl functionality. Reg µLates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Reg µLates the differentiation of the immature TECs into functional cortical TECs (cTECs) and med µLlary TECs (mTECs). Essential for maintenance of mTECs pop µLation in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a f µLly functional thymus. Plays an important role in the maintenance of hematopoiesis and partic µLarly T lineage progenitors within the bone marrow niche with age. Essential for the vasc µLarization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively reg µLating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed : 21507891).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FOXN1
Research Areas : Epigenetics and Nuclear Signaling; Immunology