FOXO1 (Ab 256) Antibody

Volume : 100 µL
Clone Number :
Aliases : FKH 1 antibody; FKH1 antibody; FKHR antibody; Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody; Forkhead box O1 antibody; Forkhead box protein O1 antibody; Forkhead box protein O1A antibody; Forkhead in rhabdomyosarcoma antibody; Forkhead; Drosophila; homolog of; in rhabdomyosarcoma antibody; FoxO transcription factor antibody; foxo1 antibody; FOXO1_HUMAN antibody; FOXO1A antibody; OTTHUMP00000018301 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q12778
Immunogen : Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A.
Raised in : Rabbit
Species Reactivity : Human, Mouse, Rat
Tested Applications : ELISA, WB, IHC, IF; WB : 1 : 500-1 : 1000, IHC : 1 : 50-1 : 200, IF : 1 : 100-1 : 200
Background :
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1 and AFX, function as key reg µLators of ins µLin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation thro µgh binding to ins µLin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

Gan L, et al. (2005) J Neurochem; 93(5) : 1209-19.
Smith WW, et al. (2005) J Cell Biol; 169(2) : 331-9.
Di Maira G, et al. (2005) Cell Death Differ; 12(6) : 668-77.
Horn S, et al. (2004) Leukemia; 18(11) : 1839-49.
Zhao X, et al. (2004) Biochem J 4; 378(Pt 3) : 839-49.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FOXO1
Research Areas : Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Metabolism;Signal transduction