FZR1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : CDC20 like 1b antibody; CDC20 like protein 1 antibody; CDC20-like protein 1 antibody; CDC20C antibody; CDH1 antibody; Cdh1/Hct1 homolog antibody; Fizzy related protein 1 antibody; Fizzy related protein antibody; Fizzy related protein homolog antibody; Fizzy-related protein homolog antibody; Fizzy/cell division cycle 20 related 1 antibody; FYR antibody; FZR 1 antibody; FZR 2 antibody; Fzr antibody; FZR_HUMAN antibody; Fzr1 antibody; Fzr1 protein antibody; FZR2 antibody; HCDH 1 antibody; HCDH antibody; hCDH1 antibody; KIAA1242 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UM11
Immunogen : Recombinant Human Fizzy-related protein homolog protein (1-493AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Key reg µLator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive reg µLators of the cell cycle do not accum µLate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint : its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1 preventing entry into mitosis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FZR1
Research Areas : Cell biology